FOLH1 - folate hydrolase 1 Gene

Also Known as PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2346

About FOLH1

Cytogenetic location: 11p11.12 Genomic coordinates (GRCh38): 11:49,145,092-49,208,602 (from NCBI)

This gene has 13 transcripts (splice variants), 212 orthologues and 5 paralogues. Biased expression in duodenum (RPKM 94.9), prostate (RPKM 43.3) and 6 other tissues.

Summary

This gene encodes a type II Transmembrane Glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate Carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate Cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

FOLH1 Products (6)

mRNA	Protein	Name
NM_001014986.3	NP_001014986.1	glutamate carboxypeptidase 2 isoform 2
NM_001193471.3	NP_001180400.1	glutamate carboxypeptidase 2 isoform 3
NM_001193472.3	NP_001180401.1	glutamate carboxypeptidase 2 isoform 4
NM_001193473.3	NP_001180402.1	glutamate carboxypeptidase 2 isoform 5
NM_001351236.2	NP_001338165.1	glutamate carboxypeptidase 2 isoform 6
NM_004476.3	NP_004467.1	glutamate carboxypeptidase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Ac-Asp-Glu binding	IDA IDA: Inferred from direct assay	24863754	GOA
enables metallocarboxypeptidase activity	IDA IDA: Inferred from direct assay	12949938	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables tetrahydrofolyl-poly(glutamate) polymer binding	IDA IDA: Inferred from direct assay	24863754	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in C-terminal protein deglutamylation	IDA IDA: Inferred from direct assay	12949938	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	12949938	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	12949938	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12949938	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOLH1 Protein Structure

Peptidase_M28

TFR_dimer

0
200
400
600
750 a.a.

Protein Preferred Names	Protein Names
glutamate carboxypeptidase 2	N-acetylated alpha-linked acidic dipeptidase 1

Recombinant FOLH1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70548	PSMA Protein, Human (HEK293, His, solution)	Q04609-1 (K44-A750)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76703	PSMA Protein, Human (Biotinylated, HEK293, His)	Q04609-1/NP_004467.1 (K44-A750)	≥ 90%, as determined by reducing SDS-PAGE.

FOLH1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82019	PSMA Antibody (YA1764)	WB	Human
HY-P82019A	PSMA Antibody (YA1764)(PBS only)	WB	Human
HY-P84480	PSMA Antibody (YA4177)	WB, FC, ELISA	Human
HY-P84480A	PSMA Antibody (YA4177)(PBS only)	WB, FC, ELISA	Human
HY-P86313	PSMA Antibody (YA6005)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hyperhomocysteinemia
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Lymph Node Carcinoma	Lymph Node Cancer Lymph Node Neoplasm Neoplasm Of Lymph Node
Prostate Disease	Prostatic Diseases Prostate Diseases
Canavan Disease	Aspartoacylase Deficiency Aminoacylase 2 Deficiency Spongy Degeneration Of Central Nervous System Aspa Deficiency Acy2 Deficiency Canavan-Van Bogaert-Bertrand Disease Mild Canavan Disease Asp Deficiency Spongy Degeneration Of The Central Nervous System Severe Canavan Disease Von Bogaert-Bertrand Disease Canavan'S Disease Spongy Degeneration Of The Brain Juvenile Canavan Disease Infantile Canavan Disease Neonatal Canavan Disease CAND Disease, Canavan Canavan Disease, Juvenile Canavan Disease, Infantile Canavan Disease, Neonatal
Anthracosilicosis
Castration-Resistant Prostate Carcinoma	Prostatic Neoplasms, Castration-Resistant
Bladder Lateral Wall Cancer	Lateral Wall Of Bladder Malignant Neoplasm Of Lateral Wall Of Urinary Bladder
Prostatic Hyperplasia, Benign	Benign Prostatic Hyperplasia BPH Prostatic Hyperplasia
Maxillary Sinus Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Maxillary Sinus Adenoid Cystic Carcinoma Of The Maxillary Sinus
Prostatic Acinar Adenocarcinoma	Acinar Prostate Adenocarcinoma
Urethral Stricture	Ankylurethria Urethral Stenosis Urethral Contracture Urethral Obstruction Meatal Stenosis Nos Constriction Of Urethra Contraction Of Urethra Stricture Of Urinary Meatus Urethral Obliteration Urethral Narrowing Pinpoint Meatus Pinhole Meatus Nos Urethral Occlusion
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Paraurethral Gland Cancer	Malignant Tumor Of Paraurethral Gland Malignant Tumor Of The Paraurethral Gland Skene Gland Carcinoma Carcinoma Of The Paraurethral Gland Paraurethral Gland Carcinoma
Lymphocele	Lymph Cyst Lymphocele Adverse Event
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Prostate Small Cell Carcinoma	Small Cell Carcinoma Of Prostate Prostate Oat Cell Carcinoma
Mucocele Of Salivary Gland	Ranula Salivary Cyst Salivary Gland Mucocele Mucous Retention Cyst Of Salivary Gland Retention Cyst Of Salivary Gland Sialocele Cyst Of Salivary Gland Or Duct Extravasation Cyst Of Salivary Gland
Prostatic Hypertrophy	Benign Prostatic Hypertrophy Prostatic Hyperplasia
Nodular Prostate
Suppression Of Tumorigenicity 12	Prostate Adenocarcinoma Adenocarcinoma Of Prostate ST12 Prostate Adenocarcinoma 1 Pac1
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Primary Cutaneous Amyloidosis	Plca Primary Localized Cutaneous Amyloidosis Familial Primary Localized Cutaneous Amyloidosis Amyloidosis Ix Lichen Amyloidosis Familial Amyloidosis, Primary Cutaneous Pca Amyloidosis 9 Amyloidosis Familial Cutaneous Lichen Fplca Familial Lichen Amyloidosis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Kidney Cancer	Renal Cancer Renal Carcinoma Kidney Neoplasm Malignant Neoplasm Of Kidney Except Pelvis Malignant Tumour Of Kidney Kidney Neoplasms Cancer, Kidney Cancer, Renal Malignant Neoplasm Of Kidney Renal Cell Carcinoma
Male Reproductive Organ Cancer	Genital Neoplasms, Male Male Genital Cancer Male Genital Neoplasm Male Reproductive System Neoplasm Malignant Neoplasm Of Male Genital Organ Malignant Neoplasm Of Male Genital Organ Or Tract Malignant Neoplasm Of Male Genital Organs Malignant Tumor Of Male Genital Organ Malignant Tumor Of Male Reproductive System Neoplasm Of Male Genital Organ Tumor Of Male Reproductive System
Male Reproductive System Disease	Genital Diseases, Male Disorder Of Male Reproductive System
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Prostate Neuroendocrine Neoplasm	Neuroendocrine Tumor Of The Prostate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991708	Olsutamig	Inhibitor	99.00%	Phase 2
HY-P990752	Nezastomig		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05028	FOLH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18175	Folh1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24649	Folh1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991359	Anti-FOLH1/PSMA Antibody (J591)	Inhibitor	95.05%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FOLH1	MGD	MGI:1858193
Rattus norvegicus	FOLH1	RGD	RGD:70963
Others	FOLH1	NCBI